Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification
نویسندگان
چکیده
منابع مشابه
Channel Through Modification of a Hydrophobic Seal
The primary activation gate in K channels is thought to reside near the intracellular entrance to the ion conduction pore. In a previous study of the S6 activation gate in Shaker (Hackos et al., 2002), we found that mutation of V478 to W results in a channel that cannot conduct ions even though the voltage sensors are competent to translocate gating charge in response to membrane depolarization...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2017
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.7b00168